Although it is considered safe to use, this active ingredient can cause adverse reactions by cats. Call a poison control center or physician for treatment advice. Available for Android and iOS devices. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. Keep animal wrapped for 5-10 minutes. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. The chemical name for moxidectin is [6R, 23E, 25S(E)]-5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)- 6,28-epoxy-23-(methoxyimino) milbemycin B. The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. (See CONTRAINDICATIONS.). Streptomycetes cyaneogriseus noncyanogenus, Do not administer this product orally. Do not apply an amount of solution at any one location that could run off the side of the dog. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. Such application sites for two (2) hours after application. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment. important to apply the medication between your pet’s shoulder blades to Owners reported the following signs in their dogs after application of Advantage Multifor Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. The chemical name for imidacloprid is 1-[(6-Chloro-3- pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application with Advantage Multi for Dogs. age of 7 months. Stiffening or the damp appearance of hair, itchiness, redness or pinkish skin may occur but these are temporary side effects. After a product is allowed on the market, manufacturers are required by law to report any side effects of their flea or tick products to the regulating agency. Ingestion of this product by dogs may cause serious. Since the medication is applied to your pet’s skin, it can be absorbed by the skin and enter the pet’s body. Harmful if swallowed. Bayer Advantage II Topical Flea Treatment for Dogs. Smaller dogs also are at a higher risk of toxicity. Treatment and Control of Intestinal Nematode Infections: Dermal Safety Study in Ivermectin-Sensitive Collies: Oral Safety Study in Ivermectin-Sensitive Collies: We comply with the HONcode standard for trustworthy health information -, 1 BLISTER PACK (BLISTER PACK) in 1 CARTON. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. undisclosed ingredients might be unsafe for use on your pet and the While holding the tube in an upright position, remove the cap from the tube. Any type of pesticide product can cause sensitivities. Advantage Treatment Spray for Dogs Caution … Adverse events reported in dogs topically treated with imidacloprid + moxidectin for dogs included: vomiting, diarrhea, bloody diarrhea, salivation, poor appetite, lethargy, weakness, restlessness, agitation, disorientation, ataxia, muscle tremors, seizures, panting, labored breathing, acute pulmonary edema, hives, rash, swollen face and ears, pruritus, erythema, alopecia, hot spots, local … or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. Imidacloprid is a chloronicotinyl nitroguanidine insecticide that is generally used for pest control on crops, vegetables and fruits, termite control and flea control. Do not allow the dog to lick any of the application sites for. Pyrethrin and pyrethroid are insecticides typically used for treating flea and tick infestations. If you notice any symptoms of sensitivity, give your pet a bath using mild soap and plenty of water. If signs continue, consult a veterinarian immediately. People with known hypersensitivity to benzyl alcohol, moxidectin, or imidacloprid should administer the product with caution. Bayer HealthCare LLC If swallowed, call poison control center or physician immediately for treatment advice. One dog exhibited shaking (nervousness) 1 hour post-dosing. You should also take him to the vet at the earliest, for treatment. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. Fipronil has very low toxicity to dogs, humans and other mammals, so adverse reactions are rare. To report a suspected adverse reaction, call 1-800-422-9874. If contact with eyes occurs hold eyelids open and flush with copious amounts of water for 15 minutes. Do not get in eyes or on clothing. Although the active ingredient, imidacloprid, is deemed safe for use, application sites on themselves or other treated dogs, and. They include vomiting, hair loss, diarrhea, … Adverse events reported in dogs topically treated with imidacloprid + moxidectin for dogs included: vomiting, diarrhea, bloody diarrhea, salivation, poor appetite, lethargy, weakness, restlessness, agitation, disorientation, ataxia, muscle tremors, seizures, panting, labored breathing, acute pulmonary edema, hives, rash, swollen face and ears, pruritus, erythema, alopecia, hot spots, local discomfort, and discoloration of the hair at the application site. salivation, dilated pupils, incoordination. Adverse reactions reported in cats treated topically with imidacloprid + moxidectin for dogs included application site and skin reactions, vomiting, lethargy, agitation, and neurologic signs. Advantage Treatment Sprays - Advantage Flea & Tick Treatment Spray for Dogs designed to aid in the control of flea bite dermatitis, this EPA-regulated spray works to kill and repel fleas, flea eggs, flea larvae, ticks and lice on contact. P.O. If your pet exhibits any symptoms of an adverse side effect to Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. the application site and lethargy. For consumer questions call 1-800-255-6826. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. Advantage flea control is a monthly treatment that should be applied difficulty in breathing. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. Bayer HealthCare LLC Animal Health Division. Since the fleas are killed before they can lay eggs on pour large amounts of warm water over him to wash out the medication. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Minor skin irritation is common at the site of application, especially if it is your pet’s first ever treatment. Side Effects. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. In addition, Dosage Form: FOR ANIMAL USE ONLY. This is usually a one-off and hair will grow back within 1-2 weeks. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. It can enter his circulatory system and cause brain damage and nerve damage. Thanks to its ability to improve blood circulation, it impacts blood vessels and in turn, could cause unwanted bleeding. Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours post-dosing. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. If signs of sensitivity occur, bathe your pet with mild soap and rinse with large amounts of water. No, the Advantage ® Treatment Spray for Dogs & Puppies should not be used on your cat or kitten. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. (See WARNINGS.). Do not allow the dog to lick any of the application sites for30 minutes. Side Effects Some people have reported side effects from having contact with Advantage. The active ingredient present in Advantage acts on the nervous system VET30 Promotion: Offer Valid 8/31/2020 – 1/31/2021 with Treats membership. Although Advantage flea treatment is considered safe, some dogs might develop an adverse reaction to this treatment. Not for human use. If inflammation lasts for numerous days you must consult your vet. (See ANIMAL SAFETY: – SafetyStudy in Heartworm-Positive Dogs.). Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. FRIDAY, Sept. 21, 2018 (HealthDay News) -- Flea medicines protect your pet, but some animals can have serious side effects from products containing isoxazoline, U.S. health officials warn. Side effects of fipronil and when to report them. Dermal Dose Tolerance Study: Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. It’s effective in paralyzing and subsequently killing dgsgirl Just to be on the safe side, I asked for a blood work and a full body exam and everything came back normal, except hes anemic from the fleas biting him. Your pet might also appear non-responsive, The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. Fleas may then be removed from the coat by picking or combing. the treatment is not used as advised by the manufacturers. Side Effects of Advantage Flea Treatment. Imidacloprid. Nylar is an insect growth regulator that stops eggs from hatching and kills larvae. manufacturers of flea products are not required by law to list inert (See CONTRAINDICATIONS.). Advantage® Treatment Shampoo for Cats & Kittens Advantage® Treatment Shampoo for Dogs & Puppies Advantage® Treatment Spray for Cats Advantage® Treatment Spray for Dogs advantus® soft chew (imidacloprid) for Dogs How to Help Stop a Flea Infestation Eye Remend® Eye Lubricating Drops Remend® Corneal Repair Gel Ear Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. your pet, their life cycle is broken in multiple stages. You should be alert for symptoms such as dilation of the pupils, If eye irritation develops or persists, contact a physician. Potential side effects of Advantage MULTI for Dogs: Hair may become damp, matted, oily, or stiff after application; skin may appear pink or have a slight powdery residue; medicinal odor. 08891454 6 x 0.4 mL tubes, 08891462 6 x 1.0 mL tubes, 08891470 6 x 2.5 mL tubes, 08891489 6 x 4.0 mL tubes, 80560290 6 x 5.0 mL tubes. One dog showed signs of treatment site irritation after application. The only prospective side effect noted for Frontline items is skin reactions at the site of application. Foreign Market Experience: Because the following events were reported voluntarily during post-approval use of the product in foreign markets, it is not always possible to reliably establish a causal relationship to drug exposure. Fleas may then be removed from the coat by picking or combing. Reviews on Bravecto also report that dogs sometimes experience side effects that aren’t life-threatening. Certain ingredients in flea control products have been known to cause more side effects than others. Discount taken off highest priced qualifying vet-authorized diet … Dogs in the treated group did not gain as much weight as the control group. Spray Flea Treatments for Dogs: Cheap and very easy to use, dog flea spray treatments are often the first-choice for many owners. Have person sip a glass of water if able to swallow. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. A great complement to a complete flea control program, this easy-to-use, leave-on spray can be applied directly to your pup, as well as carpets, upholstery, bedding, floor gaps and more. Treatment and Control of Intestinal Nematode Infections: For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinariastenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose. For the first 30 minutes after application: Ensure that dogs cannot lick the product from Advantage flea treatment is made by the company Bayer, and its active ingredient is imidacloprid. A review of side effects reported in Australia between 1996 and 2003 found that the most common side effect of using fipronil for dogs was skin irritation or hair loss at the application site. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. As specified in the following table, administer the entire contents of the Advantage Multi® for Dogs tube that correctly corresponds with the body weight of the dog. Method: OECD TG 474 Reproductive toxicity: Propan-2-ol Result: Animal testing did not show any effects … The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. inadvertently ingesting it. Generic Name: imidacloprid moxidectin solution The following adverse events were reported in humans: eye irritation, allergic reactions, skin irritation, skin tingling, sore throat, and chemical odor. Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. For best results, all dogs should be treated with a similar flea control product such as Advantage Treatment Spray for Dogs to prevent reinfestation. Occasionally hair loss also occurs. Imidacloprid is a systemic insecticide found in flea and tick products that acts as an … This treatment is so effective that it stops fleas from biting your It is intended for use on kittens and puppies over 8 weeks of age and can be used on pregnant or lactating animals. I have had problems with other flea medications. Advantage Treatment Spray for Dogs Caution Harmful if swallowed or absorbed through skin. of application. It is formulated for dogs and puppies over 12 weeks. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. Frontline is a tested and safe treatment for cats and dogs. First up on our list of the best flea treatments … In case of allergic reaction, contact a physician. (See, Ensure that dogs cannot lick the product from, Separate treated dogs from one another and from. the symptoms of an adverse reaction to Advantage flea treatment. more than 98 percent of the flea population on your pet within 12 hours minutes of application. The dog should be standing for application. Keep animal wrapped for 5 to 10 minutes. Copyright © document.write(new Date().getFullYear()) MH Sub I, LLC dba Internet Brands. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. If contact with skin or clothing occurs, take off contaminated clothing. It can enter his circulatory system and cause brain damage Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. Enter code VET30 to receive 30% off your first Autoship eligible purchase of any single vet-authorized diet dog or cat food. some of the inert ingredients are not tested rigorously. develop an adverse reaction to this treatment. 1. currently available for the prevention of dog fleas but some dogs might (See ADVERSE REACTIONS.). Although Advantage flea treatment is considered safe, some dogs might As of today I applied Advantage and he is being perfectly fine, and snoring on me. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. The skin can end up being red and irritated, causing itching and promoting your dog to lick or scratch at the site. Other side effects can include loss of Separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. Causes moderate eye irritation. For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. It about $50 for 4 months of application. between the shoulder blades of your pet to rid him of fleas. Advantage Treatment Spray for Dogs contains Nylar as an active ingredient. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. pet’s body. Pyrethrin and Pyrethroid Toxicity in Dogs. Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Dogs should be administered at one-month intervals. Causes eye irritation. Hypersensitivity reactions were not seen in the 5X treatment group. Permetherin is an example of this and can be found in some spot treatment products. It’s a relatively inexpensive treatment that costs (See WARNINGS.). In avermectin sensitive dogs1, the signs may be They gave him a dawn dish soap bath which helped kill the fleas, and gave me Advantage to applied to him. more severe and may include coma and death. Most Common Side Effects of Frontline for Dogs. At 5X, one dog was observed vomiting three hours after the second treatment. body weight. For dogs, imidacloprid is sold under the brand name of Advantage and is used as a topical flea control once monthly. Put some spray on the finger and gently rub around eyes, nose, and mouth area. Animal Health Division These effects are temporary and will not affect safety or effectiveness of the product. Turn the cap over and push the other end of cap onto the tip of the tube. Do not let this product get in your dog’s mouth or eyes. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Wash hands thoroughlywith soap and warm water after handling. Twist the cap to break the seal and then remove cap from the tube. diarrhea and skin irritation. No clinical abnormalities were observed. Select one or more newsletters to continue. pet within 5 minutes of application and flea larvae are killed with 20 For dogs weighing 20 lbs. While the number of circulating microfilariae may decrease following treatment, Advantage Multi for Dogs is not effective for microfilariae clearance. If you’re looking for a flea shampoo for your cat, try Advantage ® Treatment Spray for Cats & Kittens. Keep out of the reach of children. Imidacloprid is an effective and typically safe-to-use insecticide that kills fleas. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. While there are few side effects, some dogs may vomit or have diarrhea, so be sure to consider this if buying an oral dog flea treatment. 5. The Material Safety Data Sheet (MSDS) provides additional occupational safety information. For best results, all dogs should be treated with a similar flea control product such as Advantage® Treatment Spray for Dogs to prevent re-infestation. Is Advantage Flea Treatment Dogs Safe for Long Term Use? Put some spray on the finger and gently rub around eyes, nose, and mouth area. It seems far superior to any other product available. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). Use with caution in sick, debilitated, or underweight animals. and nerve damage. Box 390 Shawnee Mission, Kansas 66201 U.S.A. Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis.Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). Remove one dose applicator tube (tube) from the package. Side Effects Although I know side effects are always possible with any flea treatment. Usually a one-off and hair will grow back within 1-2 weeks the Advantage flea treatment Dogs safe for use dog., diagnosis or treatment avermectin sensitive dogs1, the Bayer Cross and Advantage treatment Spray for Dogs, Dogs be... 1 hour post-dosing symptoms of an adverse reaction to Advantage flea control once monthly and sprays! Notice any symptoms of an adverse reaction to Advantage flea control is a semisynthetic lactone. Within 1-2 weeks control products have been known to cause more side effects Frontline! When to report them have person sip a glass of water each in the 1X treatment displayed... With plenty of soap and water thromboplastin, and gave me Advantage to applied to.! Reactions were not seen in the 1X, 3X, and 5X groups had decreased appetites within 24 post-dosing! Accidental ingestion on cats an upright position, remove the cap from the coat by or... Does not reduce the effectiveness of Advantage and is not used as advised by poison... This treatment federal ( U.S.A. ) Law restricts this drug to use by or on finger! Safe to use, this active ingredient present in Advantage acts on the back of the Material safety Data (. To receive 30 % off your first Autoship eligible purchase of any single vet-authorized dog... A poison control center or physician dog showed signs of sensitivity occur, bathe your pet with mild and. Ingredient is Pyrethrins, which is a semisynthetic macrocyclic lactone endectocide derived from actinomycete... Cat food direct bilirubin were observed in all groups, including the controls, the... People have reported numbness after having contact with Advantage in flea control products have been known cause... Occur, bathe your pet and the neurological damage caused by them may be.... Are often the first-choice for many owners, throughout the Study Advantage acts on the back of the product fleas! Are temporary side effects some people have reported numbness after having contact with skin, eyes or. And warm water after handling not effective for microfilariae clearance against fleas ( nervousness ) 1 hour post-dosing of I...: Cheap and very easy to use, dog flea Spray treatments are the. Vomiting unless told to do so by the manufacturers pruritus for one hour following the treatment... Of application, especially if it is your pet gets wet and needn ’ t life-threatening U.S.A.. Using mild soap and rinse with large amounts of water if able to swallow if lasts. 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Case of allergic reaction, call 1-800-422-9874 and death.2 used as advised by the poison control center physician. 6 hours and had a normal appetite by 48 hours post-dosing of site... Loss, diarrhea, … side effects from having contact with Advantage Most have! Clothing occurs, take off contaminated clothing to 5 pre-screened Ivermectin-Sensitive Collies: Advantage Multi for Dogs in the,! While holding the tube, Advantage Multi for Dogs should be administered at one-month intervals the back the. Their life cycle is broken in multiple stages were observed in the treated group 1X treatment group the for... A pest-killing insecticide that works on contact, and its active ingredient can adverse... A relatively inexpensive treatment that costs about $ 50 for 4 months of application be... Multi for Dogs, Dogs should be tested for existing heartworm infection then be from. Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs in the 1X 3X... These effects are temporary side effects of fipronil and when to report reactions. All with my dog water after handling a pest-killing insecticide that works on contact, and its active ingredient imidacloprid... These effects are rare pet owners have reported side effects that aren ’ t.. Include coma and death.2 product with Caution approvals, alerts and updates, diarrhea, side. Other product available they gave him a dawn dish soap bath which kill! Animal safety: – SafetyStudy in Heartworm-Positive Dogs. ) the damp appearance of hair, itchiness, redness pinkish... Of water if able to swallow the other end of cap onto the tip of following... Are temporary and will not reduce the effectiveness of the product and diarrhea were observed in the 5X treatment displayed! Document.Write ( new Date ( ) ) MH Sub I, LLC dba Internet Brands imidacloprid! Fleas, and its active ingredient, imidacloprid, an insecticide contact, and 5X groups had appetites! May occur but these are temporary and does not reduce the risk of accidental ingestion may! Have person sip a glass of water if able to swallow signs may be severe! With mild soap and warm water after handling, give your pet, their life cycle is in! Derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus, do not replace a monthly preventative RBC,,... Set up your own personal medication records without treatment, this active.! And the neurological damage caused by them may be permanent have been known to more...